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Use of obinutuzumab was associated with significant improvements in complete renal response rate and markers of disease activity in active lupus nephritis.

Stanza previously demonstrated efficacy in helping to manage fibromyalgia in adult patients when compared with digital symptom tracking in phase 3 data.

Golimumab, marketed under the names Simponi and Simponi Aria, is approved for RA, PsA, AS, and UC.

ADI-001 now has FDA Fast Track Designation for relapsed/refractory lupus nephritis and systemic lupus erythematosus with extrarenal involvement.

Endocrinological stress indicators were not associated with perceived stress, which was related to symptom severity.

Tocilizumab-anoh will be available in both intravenous and subcutaneous formulations.

The rheumatology month in review emphasizes new research in gout, fibromyalgia, and psoriatic arthritis.

Levels of the neutrophil activation marker calprotectin correlated with NLR and MLR correlated with total number of gout attacks.

People with inflammatory bowel disease and FM tended to have a higher disease duration and reported higher rates of fatigue and lower QoL.

New research highlights the importance of immunomodulation before pegloticase exposure.

Delphi exercises revealed concordance between prioritized areas but also notable differences.

The lower BHI observed was likely associated with effects on the musculoskeletal system and not the central nervous system.

Infection and injury were the most common responsible diagnoses for patinets with both PsA or AS.

Cancer risk was examined for breast, colorectal, lung, and prostate cancer.

A post-hoc analysis evaluated pooled data from 4 trials of pegloticase.

A study found frequent comorbidity between cluster headache, fibromyalgia, and migraine, as well as heightened depression and sleep disturbance among these individuals.

Heat therapy often worsened symptoms in a randomized controlled trial.

A VR exergame may facilitate patients’ physical activity while promoting relaxation and positive mental states.

Recommendations have been largely preserved since 2018 and the USPSTF acknowledged the need for more research and better risk assessment tools.

However, gout flare states of patient acceptable symptom state, low disease activity, or not achieving either were not associated with EQ-5D-3L or HAQ.

Investigators found an incidence of 26.2 severe infections per 100 patient-years with 4 deaths in the study.

Small molecule drugs may help fill gaps in treatment with biologic therapies.

Tocilizumab and other biological drugs were particularly efficacious in lowering overall hemostatic potential, mitigating blood clot risks.

Around 37% of those had never used a bDMARD reached sustained DMARD-free remission at 5 years,

Despite improvements in PROs and disease activity, no statistically significant changes have been seen on blood biomarker analysis.

The rheumatology month in review emphasizes new research in PsA and on cardiovascular events in rheumatic disease.

An active comparator study found that incident use of gabapentin was associated with lower rates of falls than duloxetine and similar rates of severe falls.

Less than half of rheumatologists self-reported adhering to febuxostat and allopurinol dosing recommendations.

Other recent research presented at ACR 2024 found increased CVD risk with glucocorticosteroid use.