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In patients with psoriatic arthritis (PsA), guselkumab (Tremfya, Janssen Immunology) treatment reduced serum protein levels of acute phase and T-helper cell 17 (Th17) effector cytokines, achieving comparable levels to those in healthy controls.

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Healthy movement plays a critical role in the treatment of rheumatic disease because it can strengthen the muscles around the effected joints, aid in bone loss decrease, and improve joint lubrication which helps to decrease stiffness and improve pain.

Rheumatology Network interviewed Nicholas Brisson, PhD, to discuss his recent study, “Association of machine learning based predictions of medial knee contact force with cartilage loss over 2.5 years in knee osteoarthritis." The study discovered that machine learning was able to develop an equation for predicting medial tibiofemoral contact force (MCF) peak, which supports the theory that mechanical loading directly contributes to disease progression.