Studies that explore the efficacy and safety of JAK inhibitors for rheumatoid arthritis are among those we selected as most noteworthy in 2019. Also, at the top of the list, a study that shows glucocorticoids, not necessarily biologics, raise the infection risk after joint replacement surgery. Learn more in this slideshow.
Biologics, JAK inhibitors, and opioid alternatives all served major payoffs in the field in the 2010s.
Xcenda, an AmerisourceBergen company, has just published a white paper that demonstrates the prevalence of step therapy and its potential negative impact on rheumatology patients. The authors of the report say the practice doesn’t always have the best interest of patents in mind and payers don't entirely disagree. Learn more in this report.
In this month's rheumatoid arthritis quiz, we focus on contraception, a patient's preference for tapering and the self-management of flares.
Sociodemographic, physician, and insurance coverage influences who receives biologic DMARD therapy, findings of a cohort study found.
A new discontinuation strategy for infliximab in patients with rheumatoid arthritis, in which the biologic dose was determined by the serum level of tumor necrosis factor (TNF)-α, was unsuccessful for sustained biologic-free remission, say researchers recently writing in Annals of the Rheumatic Diseases.
Patients with rheumatoid arthritis who are physically active are less likely to report cognitive difficulties, say researchers recently writing in ACR Open Rheumatology.
Ultra-low doses of rituximab (Rituxan, MabThera) used as maintenance treatment for rheumatoid arthritis in patients who responded well to this agent did not show non-inferiority, but could nevertheless be considered in clinical practice, say researchers recently writing in The Lancet Rheumatology.
More than half of rheumatoid arthritis patients had persistent moderate-to-high disease activity after six months of treatment with a conventional synthetic disease-modifying anti-rheumatic drug (csDMARD), and less than a third had their therapy escalated, indicating that there is considerable need for a treat-to-target approach to care for these patients, say researchers recently writing in Clinical Rheumatology.
Even though senior patients with rheumatoid arthritis receive biologic therapies less often than patients who develop the condition early in life, a Japanese study presented this month at the ACR annual meeting, shows that patients 60 years and older can benefit from therapy just as much as younger patients.
Researchers are exploring the possibility of using immune checkpoint inhibitors in rheumatoid arthritis patients. A small study presented at the American College of Rheumatology (ACR) annual meeting earlier this month shows that rheumatoid arthritis (RA) patients who were treated with immunotherapy, responded just as well as a comparable patient population with only 12 of 22 patients experiencing flares.
A new study shows that the clinical status of patients who have either rheumatoid arthritis or axial spondyloarthritis, can be successfully maintained when switching from the biologic originator etanercept to a biosimilar called SB4.
Scientists now have a better understanding of the relationship between the gut microbiome and rheumatoid arthritis.
In today's installment of the rheumatoid arthritis clinical quiz, we examine treatment options for patients with established disease. Is sustained treatment with csDMARDs preferred over reducing the dose or dosing frequency of treatment? Click on the slideshow for more information.
John Sundy, MD, PhD, senior vice president of Inflammation and Respiratory Disease with Gilead Sciences, discusses the results of a pooled safety analysis examining phase 3 studies of filgotinib.
ACR Annual Meeting: Exposure to industrial emissions of fine particles matter and sulfur dioxide are associated with the presence of anti-citrullinated protein antibodies, a characteristic biomarker for rheumatoid arthritis, according to a study presented at the annual meeting of the American College of Rheumatology in Atlanta on November 12.
In rheumatoid arthritis patients who are in sustained remission and receiving conventional synthetic DMARDs, continued treatment with stable doses led to fewer disease activity flares and less frequent radiographic joint damage progression than tapered csDMARD treatment, shows a study.
John Sundy, MD, PhD, senior vice president of Inflammation and Respiratory Disease with Gilead Sciences, discusses the results of the 156-week analysis of filgotinib in RA patients.
A new study from ACR 2019 found tocilizumab outperformed rituximab in rheumatoid arthritis patients with low B-cell levels.
Daniel Clauw, MD, of the University of Michigan, discusses how the diagnosis of a rheumatic condition can impact the mental health of patients.
Jeffrey Curtis, MD, discusses how the Vectra test can be a useful tool for rheumatologists at ACR 2019.
An analysis of more than 7000 patients presented at ACR 2019 found there was no significant differences in safety or efficacy of biologic DMARDs based on the age of RA onset.
ACR Annual Meeting: A large proportion of patients with rheumatoid arthritis achieved remission with either active conventional therapy or with one of three different biologic therapies, certolizumab, abatacept and tocilizumab, after 24 weeks of treatment, according to a study presented at the annual meeting of the American College of Rheumatology in Atlanta on November 12.
ACR Annual Meeting: Methotrexate should be continued in most patients with active rheumatoid arthritis when biologic or targeted synthetic therapy is initiated, EU researchers reported in a poster presentation on November 12 at the annual meeting of the American College of Rheumatology in Atlanta.
ACR Annual Meeting: The anti-IL-6 agent olokizumab was safe and effective when added to methotrexate in patients with rheumatoid arthritis in a phase three randomized controlled trial, researchers reported on November 12 at the American College of Rheumatology annual meeting in Atlanta.
