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(AUDIO) The primary challenge in lupus diagnosis is nonspecific signs and lack of good biomarkers, says Sam Lim, MD, of the American College of Rheumatology’s Lupus Initiative. Here he sheds light on how to arrive at an appropriate diagnosis.

A 27-year-old white man, an active-duty soldier who previously had been healthy, presented with a 5-month history of progressively worsening swelling, pain and, eventually, skin hardening in both legs and then arms

The cause of neck pain, or cervicalgia, can usually be identified by history and physical exam. Learn the provocative maneuvers and "red flag" symptoms to exclude malignancy and reveal radiculopathy or myelpathy.

The original antiphospholipid syndrome (APS) classification criteria (the Sapporo criteria), published in 1999, helped galvanize research in this disorder.1 New clinical, laboratory, and experimental insights gained since then were addressed at the Eleventh International Congress on Antiphospholipid Antibodies in Sydney, Australia, in 2006.

Iliopsoas Bursitis

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Anterior hip pain sometimes arises from iliopsoas bursitis, which may present as a groin mass. Pain may be referred to the abdomen, thigh, or knee.

Eosinophilic fasciitis (EF), also known as Shulman disease and diffuse fasciitis with eosinophilia, is an uncommon condition that often is confused with scleroderma because they have similar features.