News

The 45-year-old woman turned up in the emergency room with an acutely painful, swollen thumb. Aspiration results were uninformative. What's the diagnosis?

Neurological symptoms may be the presenting feature in lupus, sarcoidosis, vasculitis, and other rheumatic diseases, notes this review. Treatment may also cause neurological side effects including demyelination, tremor, and psychosis.

Confirming the high pneumonia risk in lupus patients, researchers in Spain have found that it may precede the onset of the immune disorder. Their biological studies suggest that a particular underlying immune abnormality may explain both.

Rheumatologists can play a key role in management of the many subtypes of cryoglobulinemia by recognizing the chief symptoms. Challenge your knowledge in this brief quiz, then read a review by experts.

A new international multicenter study of often-deadly macrophage activation syndrome in systemic JIA reveals key laboratory and clinical warning signs. Watch ferritin levels especially closely.

An eight-year study of more than 100 patients with giant cell arteritis reveals that for the majority of patients it is not an isolated episode. Relapses tend to occur within two years, usually as polymyalgia rheumatica or cranial symptoms.

Knee osteoarthritis can trigger a series of clinical problems that set patients on the road to early frailty, especially if both knees are involved. It's prudent for their physicians to be on high alert for it.

Whatever is causing this woman’s hip pain, her x-ray film looks quite severe. The diagnosis was correct 40 years ago, but it couldn’t be treated effectively then. What’s the problem?

This 28-year-old woman presented with a large hyperpigmented patch on the right side of her upper back. Although the lesion developed over the past 2 years, it has been "sinking in" over the past 2 weeks. The patient denies any trauma, pain, discomfort, or pruritis, as well as any family history of cancers, lymphoma, or autoimmune disease. However, she has a history of gastroesophageal reflux disease and onychomycosis, and her grandfather has a similar lesion.

While rhabdomyolysis has been recognized as a consequence of crush injuries since the late 1800s, the most significant step toward finding the condition's causes, mechanisms, and management strategies occurred when physicians who treated crush injuries from the 1941 London Blitz identified a link between rhabdomyolysis and renal impairment.

Combining results from studies involving nearly 12,000 rheumatoid arthritis patients finds the fusion protein etanercept less likely than other TNF inhibitors to be discontinued due to infections.