Rheumatoid Arthritis

Over one-third of participants had had inadequate responses or intolerance to at least 3 prior b/tsDMARDs.

People who used GC for over 2 years and 3 years had elevated risks of CVD and infection-related mortality, respectively, that never returned to pre-GC use levels.

While an effective and promising strategy for chronic pain relief, more research on long-term cannabis usage is needed.

Highest responders on DAS28 also had significantly greater decreases in 12-hydroxyeicosatetraenoic than low responders.

Veterans residing in rural areas were only 10% more likely to initiate biologic therapies than those residing in rural areas.

Week 156 efficacy and safety data from the FINCH 4 study are consistent with that seen in FINCH 1, 2, and 3.

Patients exposed to screening were also more likely to receive vaccinations and consult a cardiologist and/or a pneumologist.

Investigators analyzed antibody response after 2 SARS-CoV-2 vaccinations.

The all-optical PAT scanner reduces acquisition time from minutes to seconds and can visualize microvasculature changes to depths approaching 15 mm.

More research is needed to investigate changing trends at presentation and help to inform current treatment strategies.

The data also support the validity of further research into targeting CD-40 signaling in patients with RA not responding to treatment.

In other populations, JAKis demonstrated at least a similar pain benefit to b/tsDMARDs from baseline.

Notably, people with fewer vaccine doses were more likely to experience post-acute sequelae of COVID-19.

Hs-cTnT was found to be associated with a higher risk of MACE and all-cause mortality in a 10-year cohort study.

Patients with high RF concentration treated with CZP were more likely to achieve DAS28-CRP low disease activity at week 104 than those treated with adalimumab.

The MTX + HCQ group had a higher, but not statistically significant, incidence rate of TEAEs than the monotherapy group.

Investigators noted that a formal independent validation cohort needs to be developed in order to realize the full potential of the human model.

Lengths of stay, total cost, and hospital mortality rates were similar between patients with and without rheumatoid arthritis.

Investigators also found that bDMARDs were used more often by patients with early-onset rheumatoid arthritis than by patients with late-onset.

Adjusted analyses reveal a statistically significantly higher prescription medication cost in patients with RA compared to those without.

Results showed comparable clinically meaningful improvements in health-related quality of life among patients treated with the adalimumab reference product and biosimilar adalimumab-adbm.

Results showed particular heavy metals increased the risk of arthritis.

Inverse variance weighting showed beef intake, iron intake, process meat intake, cheese intake, and fresh and dried fruit intake were strongly linked to inflammatory arthritis.

Higher PROs, which were indicative of worse disease activity, were more likely to be reported in the spring and fall months.

Erectile dysfunction was significantly linked to arthritis and remained significant even after adjustment.